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Caroline Fife M.D
GLP-1 receptor agonists including semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), and a growing pipeline of new entrants are being prescribed to tens of millions of Americans for weight loss and diabetes management, and they are fundamentally altering how, when, and how much people eat
GLP-1 medications are not suitable for everyone
Atorvastatin has low solubility and high permeability, and shows complete intestinal absorption when orally administered, but its systemic bioavailability is only 14% as it is subject to first-pass metabolism in the gut and liver
2014;114:S229
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